Cost-effectiveness of Metered-Dose Inhalers for Asthma Exacerbations in the Pediatric Emergency Department
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چکیده
RESULTS. Compared with placebo, omalizumab treatment significantly reduced the mean number of symptomatic days per 2-week interval from 1.96 to 1.48, which is a 24.5% difference (P .001). Significantly fewer exacerbations occurred during the treatment period in the omalizumab group; 30.3% of patients had an exacerbation compared with 48.8% of patients in the placebo group (P .001). Similarly, the percentage of hospitalizations caused by asthma was 1.51% vs 6.3% in the placebo group (P .02). Asthma control in the omalizumab group required significantly lower doses of inhaled glucocorticoids (P .001) and long-acting 2 agonists (P .003). Finally, posthoc analysis revealed that omalizumab prevented the seasonal spikes in exacerbations seen in the placebo group. No differences in safety were seen.
منابع مشابه
Cost-effectiveness of metered-dose inhalers for asthma exacerbations in the pediatric emergency department.
OBJECTIVE To compare the incremental cost and effects (averted admission) of using a metered-dose inhaler (MDI) against wet nebulization to deliver bronchodilators for the treatment of mild to moderately severe asthma in pediatric emergency departments (EDs). METHODS We measured the incremental cost-effectiveness from the perspective of the hospital, by creating a model using outcome characte...
متن کاملCost-effectiveness of Metered-Dose Inhalers for Asthma Exacerbations in the Pediatric Emergency Department
RESULTS. Compared with placebo, omalizumab treatment significantly reduced the mean number of symptomatic days per 2-week interval from 1.96 to 1.48, which is a 24.5% difference (P .001). Significantly fewer exacerbations occurred during the treatment period in the omalizumab group; 30.3% of patients had an exacerbation compared with 48.8% of patients in the placebo group (P .001). Similarly, t...
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